Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. However, the minor compounds could also be of crucial importance; all the phytochemicals could synergistically act and enhance the observed activity [ cothla ]. A potent cytotoxicity was thus observed for the Cotula cinerea hexane extract which inhibited the growth of RD cell line at the lowest IC 50 value Skip to search form Skip to main content.

Cotuula Btaouri et al. Salvia verbenaca is a Mediterranean plant currently belonging to the Lamiaceae family. Further studies are obviously needed to elucidate the exact mechanism of Cotula cinerea in cytotoxic activity. On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with the lowest IC 50 value Morocco is rich in medicinal plants on which some studies have been focused on antitumor activities [ 7 — 10 ].

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Indeed, plants are rich sources of new compounds from which some secondary metabolites have been shown to possess anticancer properties [ 5 — 7 ]. Growing Wildly in the Middle East: An examination of the obtained results showed that the cytotoxic effects of the investigated plants extracts were different according to the tested cell line with an efficient activity of Cotula cinerea compared to Salvia verbenaca.


These plants are widely used in the Moroccan traditional folk medicine. Cotula is a genus of cotulaa plant in the sunflower family. Material and Methods 2. The collected aerial parts were left under shade at room temperature until complete drying. The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca xinerea addition to the essential oil of Cotula cinerea.

The concentrations that inhibit half of the cell population IC 50 were obtained by modeling the percentage of cytotoxicity versus concentration of extracts. It is thus important and imperative to find more effective drugs with a shorter application period.

Cotula – Wikipedia

The noticed differences in the observed cytotoxicity cineerea the investigated mixtures could obviously be due cindrea the phytochemical composition of each extract. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. Another characteristic is their solitary heads growing on a peduncle.

Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital. Abstract The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.

Cotula cinerea which is of coula Asteraceae family is a xerophytic plant widely distributed in sandy and desert grounds [ 11 ]. The current widely used cancer treatments such as surgery, radiotherapy, systemic therapy, and chemotherapy are very expensive and cause several side and adverse effects [ 4 ].


After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts hexane, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca. By using this site, you agree to the Terms of Use and Privacy Policy. The obtained values are correlated with the metabolized intracellular MTT concentrations and are therefore proportional to the number of living cells. Huile essentielle de Santolina africana Jord. Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed.

Topics Discussed in This Paper. The extraction was achieved during six hours and the obtained oil yield 0. Cell viability was evaluated by determination of the percentage of cytotoxicity using the formula given below.

Indeed, the explored extracts are complex mixtures containing several phytochemical compounds which could have different biological cottula. Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health cotuka, especially with the appearance of multidrug resistance cells. Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot.

The Royal Society of New Zealand. The species within this genus can vary extensively in their habitleaf divisioninvolucrereceptacle and achenes. Furthermore, natural products could be as efficient as synthetic ones with no or less toxicity and are less expensive than synthetic drugs.

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