Diazotization Titration or Nitrite Titration. Diazotization is used in the analysis of aromatic compounds containing an amino group in the. View Notes – from ECH at University of Florida. Diazotization titration (Nitrite Titration) Mr. V. M. Patil Assistant Professor & PG. Quantitative estimation of Eflornithine by Nitrite (Diazotization) titration Here the amino group of Eflornithine is diazotized with sodium nitrite solution in.
|Country:||United Arab Emirates|
|Published (Last):||15 September 2004|
|PDF File Size:||17.66 Mb|
|ePub File Size:||16.74 Mb|
|Price:||Free* [*Free Regsitration Required]|
A Seminar on Potentiometric and Diazotization Titrations
My presentations Profile Feedback Log out. What are the example drugs assayed by the diazotization titrimetry? Volumetric or titrimetric analysis are among the most useful and accurate analytical techniques, especially.
The principle involved in this method is that the excess nitrous acid is added to the titration sample solution and it is back titrated with the other appropriate titrant. Another procedure is—after maintaining the conical flask temperature, diazotizatioh pair of platinum electrodes is immersed. The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt.
They are as follows: Selective for the all types of sulphonamides. Used in the determination of the chloropheneramine.
4. Diazotization Titrations – Pharmaceutical Analysis [Book]
The obtained nitrous acid is reacted with the primary aromatic amine to form the diazonium salt. The titrztion where the EMF increases rapidly gives the end point. Based on this, the amino compounds are classified into two main groups. Another method for the detection of end point is by immersing the platinum electrodes in the resulting solution and it is also detected by the dead-stop end point method.
Used in the determination of the sulphonamides. Equivalence point is indicated by a marked deflection in the titration curve.
Pharmaceutical Analysis by P. D. Chaithanya Sudha
Analytical Chemistry Volumetric Analysis. Activity not concentration Concepts to review: Hence the non-aqueous titrimetric method is used.
What are the different methods used for dlazotization end point detection in the diazotization titrimetry? Disadvantage of fragility, imperfections in the bulb may cause error.
For example, the aminophenol is readily oxidized by the nitrous acid and converted to the quinones in the presence of copper sulphate solution and forms the diazo oxide compounds. Start Free Trial No credit card required. The excess of nitrous acid is determined by the addition of the starch iodide as an external indicator.
In non-aqueous titrations, usually, the milli volt scale of tittration is used diazotizaation than pH scale since the potential of the non-aqueous systems exceed the pH scale.
The end point is determined by the above-mentioned methods. Diazotization Titrations free pharmacy study material pharmaceutical analysis pharmaceutical analysis lecture notes. The amine reacts with the nitrous acid to form nitrosamine, which is followed by the tautomerisation and the water molecule is lost to form the diazonium ion.
Used in the determination titrahion the ephedrine.
Temperature conditions to be properly maintained throughout the reaction. The diazoization point is determined by streaking one drop of the titration solution on the starch iodide paper until blue colour is appeared.
Fritz first used this method to distinguish the aromatic and aliphatic amines by using the perchloric acid as titrant.