DOSIS OCTREOTIDE PDF

Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ┬«) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.

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The elimination half-life after s. For more information about dosing, watch the video.

Within each frequency grouping, adverse reactions are ranked in order of decreasing seriousness. Ampoule is intended for single use only; it should be opened just prior to administration and any unused portion discarded. In carcinoid tumours, if there is no beneficial response within 1 week of treatment with Octreotide at the maximum tolerated dose, therapy should not be continued.

Prior to administration the solution should be inspected visually for changes of colour or solid particles. Sandostatin produces improvement of diarrhoea, and hence weight gain, in those patients affected. Metabolism and nutrition disorders.

Name of the medicinal product 2. The following adverse drug reactions, listed in Table 1, have been accumulated from clinical studies with octreotide:.

Since, following bleeding episodes from oesophageal varices, there is an increased risk for the development of insulin-dependent diabetes or for changes in insulin requirement in patients with pre-existing diabetes, an appropriate monitoring of blood glucose levels is mandatory.

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In emergency situations may be given by IV bolus undiluted over 3 to 5 minutes. Find out more here. General disorders and administration site conditions.

Octreotide’s effects in the different tumour types are as follows: Somatostatin dosie analogues, ATC code: Concomitant administration of octreotide and bromocriptine increases the bioavailability of bromocriptine. Last updated on eMC: From a microbiological point of view, the diluted solution should be used immediately.

Gallbladder abnormalities eg, gallstones, biliary sludgeGI upset, bradycardia, conduction abnormalities, arrhythmias, hyperglycemia, hypoglycemia, hypothyroidism, injection site pain, headache, dizziness, pancreatitis, altered dietary fat absorption.

In cirrhotic patients with octeeotide gastro-oesophageal varices. Beginning with this low dose may permit adaptation to adverse gastrointestinal effects for patients who will require higher doses.

Dose adjustments of medicinal products such as beta blockers, calcium channel blockers, or agents to control fluid and electrolyte balance, may be necessary see section 4. Diarrhoea, abdominal pain, nausea, constipation, flatulence. When these occur, they mostly affect the skin, rarely the mouth and airways.

Sandostatin has been found to reduce the intestinal absorption of ciclosporin and to delay that of cimetidine. Skin and subcutaneous tissue disorders Urticaria.

Dosing & Administration

Patients should not breast-feed during Octreotide treatment. Cholecystitis, biliary sludge, hyperbilirubinaemia Metabolism and nutrition disorders Very common: Unlike somatostatin, octreotide inhibits GH secretion preferentially over insulin and its administration is not followed by rebound hypersecretion of hormones i.

The frequency of gastrointestinal adverse events is known to decrease over time with continued treatment. Step 12 Immediately dispose of syringe in a sharps container Special precautions for disposal: Neoplastic lesions were dosjs observed either in mice receiving daily s. Hypothyroidism, thyroid disorder octreeotide.

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Sandostatin® LAR Depot Dosing & Administration | HCP

Hypoglycaemia, impaired glucose tolerance, anorexia. To reduce local discomfort, it is recommended that the solution should be at room temperature before injection. Hypersensitivity and allergic reactions have been reported during post-marketing experience. Repeat moderate shaking for another 30 seconds if the powder is not completely suspended. The amount of Octreotide bound to blood cells is negligible.

Mimics the action of naturally occuring somatostatin and decreases the secretion of gastroenterohepatic peptides that may contribute to adverse symptoms in patients with metastatic tumors, VIPomas. Active ingredient octreotide acetate. Thus, the abovementioned observations were transient and considered to be the consequence of GH inhibition. Dizziness Endocrine disorders Common: A maximum dose of 1.

Bradycardia, arrhythmia, conduction abnormalities, and other EKG changes may occur. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme, Website: Sandostatin LAR Depot is available in 10 mg, 20 mg, and 30 mg for up or down dose titration. Mixing pctreotide Administration Guide Injection should be administered by a health care professional immediately after it is mixed.

Hypoglycemia or hyperglycemia may occur. This is accompanied by an improvement dosus associated electrolyte abnormalities, e. The management of overdosage is symptomatic.

Injection should be administered by a health care professional immediately after it is mixed.

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